Does a Hookworm Toxin Exist?
نویسندگان
چکیده
Many investigations have been devoted to the solution of the problem of the mechanism by which the hookworm exerts its deleterious effects. There is no doubt that the answer to the question is as complex as the syndrome produced by the hookworm. Loss of blood due to the sucking worm, increased by the prolonged oozing from the abandoned bites in jejunum and duodenum, is certainly one factor concerned in causing anaemia; this anaemia is responsible, due to the anoxaemia accompanying it, for the myocardial damage in the majority of cases. Many authors think that the amount of blood lost in this way is not sufficient to explain the extreme degree of anaemia which so frequently is encountered in ancylostomiasis, though the quantity of blood drawn by one worm daily is estimated as being between 0.38 and 0.84 c.cm. (c/. Strong, 1942). Since most of our hookworm patients suffer from malaria and from intestinal infec-
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